Bonjour chez Wolfgang Raffelsberger
General Research Interest : Bioanalysis, Bioinformatics, Functional Genomics, Biostatistics
Specialization : Automatic Analysis, Transcriptomics, CGH, Deep Sequencing, Experimental Design
Software :
RReportGenerator
Luu TD, Rusu A, Walter V, Linard B, Poidevin L, Ripp R, Moulinier L, Muller J, Raffelsberger W, Wicker N, Lecompte O, Thompson JD, Poch O, Nguyen H
KD4v: comprehensible knowledge discovery system for missense variant.
Nucleic Acids Res. 2012 Jul;40(Web Server issue):W71-5. PMID: 22641855
Delyfer MN, Raffelsberger W, Mercier D, Korobelnik JF, Gaudric A, Charteris DG, Tadayoni R, Metge F, Caputo G, Barale PO, Ripp R,
Muller JD, Poch O, Sahel JA, Léveillard T.
Transcriptomic analysis of human retinal detachment reveals both inflammatory response and photoreceptor death.
PLoS One. 2011;6(12):e28791. PMID: 22174898
Guérin E, Raffelsberger W, Pencreach E, Maier A, Neuville A, Schneider A, Bachellier P, Rohr S, Petitprez A,
Poch O, Moras D, Oudet P, Larsen AK, Gaub MP, Guenot D.
In vivo topoisomerase I inhibition attenuates the expression of Hypoxia Inducible Factor 1 alpha target genes and decreases tumor angiogenesis.
Mol Med. 2012 Feb 10;18:83-94. PMID: 22033674
Lupberger J, Zeisel MB, Xiao F, Thumann C, Fofana I, Zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J,
Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoël M, Raffelsberger W, Poch O, McKeating JA, Brino L, Baumert TF.
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
Nat Med. 2011 May; 17(5):589-95. PMID: 21516087
Berge C, Froloff N, Kalathur RKR, Maumy M, Poch O, Raffelsberger W, Wicker N.
Multidimensional Fitting for Multivariate Data Analysis.
J Comput Biol. 2010 Feb 22; 17(5):723-32. PMID: 20175691
Cronin T, Raffelsberger W, Lee-Rivera I, Jaillard C, Niepon ML, Kinzel B, Clérin E, Petrosian A, Picaud S, Poch O, Sahel JA, Léveillard T.
The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress.
Cell Death Differ. 2010 Feb 5; 17(7):1199-210. PMID: 20139892
Soyer J, Flasse L, Raffelsberger W, Beucher A, Orvain C, Peers B, Ravassard P, Vermot J, Voz ML, Mellitzer G, Gradwohl G.
Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.
Development. 2010 Jan; 137(2):203-12. PMID: 20040487
Kalathur RKR, Gagniere N, Berthommier G, Poidevin L, Raffelsberger W, Ripp R, Léveillard L, Poch O.
RETINOBASE: a web database, data mining and analysis platform for gene expression data on retina.
BMC Genomics. 2008, 9:208. PMID: 18457592
Thiersch M, Raffelsberger W, Frigg R, Samardzija M, Wenzel A, Poch O, Grimm C.
Analysis of the retinal gene expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection.
BMC Genomics. 2008, 9:73. PMID: 18261226
Raffelsberger W, Krause Y, Mouliner L, Kieffer D, Morand AL, Brino L, Poch O
RReportGenerator : Automatic reports from routine statistical analysis using R.
Bioinformatics 2008, 24(2):276-278. PMID: 18037684
Calza S, Raffelsberger W, Ploner A, Sahel J, Leveillard T, Pawitan Y
Filtering genes to improve sensitivity in oligonucleotide microarray data analysis.
Nucleic Acids Res. 2007, 35(16) e102. PMID: 17702762
Yin W, Raffelsberger W, Gronemeyer H
Retinoic acid determines life span of leukemic cells by inducing antagonistic apoptosis-regulatory programs.
J Biochem Cell Biol. 2005, 37(8):1696-708. PMID: 15869897
Raffelsberger W, Dembele D, Neubauer MG, Gottardis MM, Gronemeyer H.
Quality indicators increase the reliability of microarray data.
Genomics. 2002, 80(4):385-94. PMID: 12376092
Wicker N, Dembele D, Raffelsberger W, Poch O.
Density of points clustering, application to transcriptomic data analysis.
Nucleic Acids Res. 2002, 30(18):3992-4000. PMID: 12235383
Altucci L, Rossin A, Raffelsberger W, Reitmair A, Chomienne C, Gronemeyer H.
Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.
Nat Med. 2001, 7(6):680-6. PMID:11385504
Benoit G, Altucci L, Flexor M, Ruchaud S, Lillehaug J, Raffelsberger W, Gronemeyer H, Lanotte M.
RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.
EMBO J. 1999, 18(24):7011-8.
Raffelsberger W., and Wittliff J.L.
A Novel Approach For Comparing Ligand Binding Results From Titration And Competition Analyses To Study Hormone Mimics
J Clin Ligand Assay, 20 (4): 275 - 280, 1997
Wittliff J.L. and Raffelsberger W.
Mechanisms of Signal Transduction : Sex Hormones, Their Receptors and Clinical Utility.
J Clin Ligand Assay, 18 (4): 211 - 241, 1995
Eckhart L, Raffelsberger W, Ferko B, Klima A, Purtscher M, Katinger H, Ruker F.
Immunogenic presentation of a conserved gp41 epitope of human immunodeficiency virus type 1
on recombinant surface antigen of hepatitis B virus. PMID: 8810996
J Gen Virol. 1996, 77 (Pt 9):2001-8.
Graumann K, Wittliff JL, Raffelsberger W, Miles L, Jungbauer A, Butt TR.
Structural and functional analysis of N-terminal point mutants of the human estrogen receptor.
J Steroid Biochem Mol Biol. 1996, 57(5-6):293-300. PMID: 8639465
Monograph Chapters :
Thiersch M, Raffelsberger W, Frigg E, Samardzija M, Blank P, Poch O and Grimm C.
The Hypoxic Transcriptome of the Retina: Identification of Factors with Potential Neuroprotective Activity.
in book : Recent Advances in Retinal Degeneration.
Volume 613 (2008), Springer, ISBN 978-0-387-74902-0 (Print) 978-0-387-74904-4 (Online), 75-85.
Scientific Editor Acitivity :
since 2011 associate editor of ISRN Biomathematics
Recent / Past Events :
Teaching transcriptomics and proteomics course + practicals to M2 students at UdS , 2011/12 and 2012/13 , Strasbourg, France
IGBMC international PhD course Transfected Cell Array : Bioinformatics part + practicals , March 24-30, 2011, IGBMC, Strasbourg, France
Bioconductor Developer Meeting Europe Flashlight talk GxTools - Automating transcriptome analysis , November 17-18, 2010, EMBL, Heidelberg, Germany
IGBMC PhD & Post-Docs Functional Genomics Workshop Introduction and Transcriptomics part + practicals , July 5 & 10, 2010, IGBMC, Strasbourg, France
UseR! 2009 Meeting Focus talk (Association Studies): Analysis of deep sequencing data to study tumor biology , July 8-10, 2009, Agrocampus-Ouest, Rennes, France
Computational and Statistical Aspects of Microarray Analysis (CSAMA09) Flashlight presentation : Study of genomic abnormalities in cancer biopsies , June 14-19, 2009, Bressanone-Brixen, Italy
Swiss Eye Research Meeting Invited "Special Lecture" : Transcriptomics in Vision Research: Essentials, Pitfalls and Perspectives , Feb 10 -11, 2009, Kongresshaus Bienne/Biel, Switzerland,
Teaching transcriptomics module to M2 students at Université Henri Poincaré , 17 September 2008, Nancy, France
Presentation at useR! 2008 "RReportGenerator: Automatic reports from routine statistical analysis using R" (section 'Reporting'), 13 August 2008, Dortmund, Germany
Bioinformatics Seminar at LORIA "Analyse transcriptomique du cancer colorectal", 5 May 2008, Nancy, France
Scientific organizer of the R and Bioconductor Training Course, March 26-28, 2008, Strasbourg, France
Workshop on bioinformatics and modelling in biomedicine: from genes to biological systems :
Luxembourg, 27 October 2006 : invited speaker :
Processing and Quality control of transcriptomic data
Teaching at ULP , 2005/06, 2006/07, 2007/08 :
Ecole Doctorale Module
"Bioinformatique à l'ère post-génomique": Transcripomique
European Retinal Research Training Network (RetNet) :
Scientific organizer of
RetNet
BioInformatics Course, March 7-9, 2005, IGBMC, Strasbourg, France