Bonjour chez
Wolfgang Raffelsberger
Laboratoire
BioInformatique et Génomique Intégratives,
Département de Biologie et Génomique
Structurales (CNRS
UMR7104),
IGBMC, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
Tel (+33)/0 388 65 33 00
wolfgang.raffelsberger (at) igbmc.fr
General Research Interest : Bioanalysis, Bioinformatics, Functional Genomics, Biostatistics
Specialization : Transcriptomics, CGH, Deep Sequencing, Automatic Analysis, Experimental Design
Software : RReportGenerator
Teaching :
Data for practice
Publications :
Kalathur RKR, Gagniere N, Berthommier G, Poidevin L, Raffelsberger W, Ripp R, Léveillard L, Poch O.
RETINOBASE: a web database, data mining and analysis platform for gene expression data on retina.
BMC Genomics. 2008, 9:208.
Thiersch M, Raffelsberger W, Frigg R,
Samardzija M, Wenzel A, Poch O, Grimm C.
Analysis of the retinal gene
expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection.
BMC Genomics. 2008, 9:73
Raffelsberger W, Krause Y, Mouliner
L, Kieffer D, Morand AL, Brino L, Poch O
RReportGenerator : Automatic reports
from routine statistical analysis using R.
Bioinformatics 2008, 24(2):276-278
Calza S, Raffelsberger W, Ploner A,
Sahel J, Leveillard T, Pawitan Y
Filtering genes to improve
sensitivity in oligonucleotide microarray data analysis.
Nucleic Acids Res. 2007, 35(16) e102.
Yin W, Raffelsberger W, Gronemeyer H
Retinoic acid determines life span
of leukemic cells by inducing antagonistic apoptosis-regulatory programs.
Int
J Biochem Cell Biol. 2005, 37(8):1696-708.
Raffelsberger W, Dembele D, Neubauer
MG, Gottardis MM, Gronemeyer H.
Quality
indicators increase the reliability of microarray data.
Genomics.
2002, 80(4):385-94. supplemental data
Wicker N, Dembele D, Raffelsberger
W, Poch O.
Density of
points clustering, application to transcriptomic data analysis.
Nucleic
Acids Res. 2002, 30(18):3992-4000.
Altucci L, Rossin A, Raffelsberger
W, Reitmair A, Chomienne C, Gronemeyer H.
Retinoic
acid-induced apoptosis in leukemia cells is mediated by paracrine action of
tumor-selective death ligand TRAIL.
Nat
Med. 2001, 7(6):680-6.
Benoit G, Altucci L, Flexor M,
Ruchaud S, Lillehaug J, Raffelsberger W, Gronemeyer H, Lanotte M.
RAR-independent
RXR signaling induces t(15;17) leukemia cell maturation.
EMBO
J. 1999, 18(24):7011-8.
Raffelsberger W., and Wittliff J.L.
A Novel
Approach For Comparing Ligand Binding Results From Titration And Competition
Analyses To Study Hormone Mimics
J Clin
Ligand Assay, 20 (4): 275 - 280, 1997
Wittliff J.L. and Raffelsberger W.
Mechanisms
of Signal Transduction : Sex Hormones, Their Receptors and Clinical Utility.
J Clin
Ligand Assay, 18 (4): 211 - 241, 1995
Eckhart L, Raffelsberger W, Ferko B,
Klima A, Purtscher M, Katinger H, Ruker F.
Immunogenic
presentation of a conserved gp41 epitope of human immunodeficiency virus type 1
on recombinant surface antigen of hepatitis B virus.
J Gen
Virol. 1996, 77 (Pt 9):2001-8.
Graumann K, Wittliff JL,
Raffelsberger W, Miles L, Jungbauer A, Butt TR.
Structural
and functional analysis of N-terminal point mutants of the human estrogen
receptor.
J
Steroid Biochem Mol Biol. 1996, 57(5-6):293-300.
Monograph Chapters :
Thiersch M, Raffelsberger W, Frigg
E, Samardzija M, Blank P, Poch O and Grimm C.
The Hypoxic Transcriptome of the
Retina: Identification of Factors with Potential Neuroprotective Activity. in
Book Recent Advances in Retinal Degeneration.
Volume 613 (2008), Springer
Recent / Past Events :
UseR! 2009 Meeting
Focus talk (Association Studies): Analysis of deep sequencing data to study tumor biology
, July 8-10, 2009, Agrocampus-Ouest, Rennes, France
Computational and Statistical Aspects of Microarray Analysis (CSAMA09)
Flashlight presentation : Study of genomic abnormalities in cancer biopsies
, Bressanone-Brixen, Italy, June 14-19, 2009
Swiss Eye Research Meeting Invited "Special Lecture" :
Transcriptomics in Vision Research: Essentials, Pitfalls and Perspectives
, Kongresshaus Bienne/Biel, Switzerland, Feb 10 -11, 2009,
Teaching transcriptomics module to M2 students at Université Henri Poincaré
, Nancy, 17 September 2008
Presentation at useR! 2008
"RReportGenerator: Automatic reports from routine statistical analysis using R" (section 'Reporting'), Dortmund, 13 August 2008
Bioinformatics Seminar at LORIA
"Analyse transcriptomique du cancer colorectal", Nancy, 5 May 2008
Scientific
organizer of the R
and Bioconductor Training Course,
Workshop
on bioinformatics and modelling in biomedicine: from genes to biological
systems :
Teaching at ULP , 2005/06, 2006/07, 2007/08 :
Ecole Doctorale Module
«Bioinformatique à l'ère post-génomique»: Transcripomique
European Retinal Research Training Network (RetNet) :
Scientific organizer of
RetNet
BioInformatics Course, IGBMC, March 7-9, 2005
Le département de Biologie et Génomique Structurales